Chemistry Reference
In-Depth Information
with cyclodextrin dimers and double-ended substrates showed that the special chelate
effect was reflected in the enthalpies [185]. Entropy-enthalpy compensation is not an
unusual phenomenon. We performed a number of such studies, including one in
which we were able to quantitate the binding energy that could be ascribed to the hy-
drophobic effect [186].
We also investigated chelate binding by dimers of a synthetic hydrophobic macro-
cycle, in place of the cyclodextrins [187]. In the systems examined the chelate effect was
weaker than that seen with the cyclodextrin dimers. We also studied the strong binding
of cholesterol by some cyclodextrin dimers and a cyclodextrin polymer, and saw that
the large sterol could occupy parts of two binding cavities [188].
