Chemistry Reference
In-Depth Information
diester bonds of DNA under mild conditions. Over the past several decades, much has
been learned about the mechanistic role of metal ions for a wide range of hydrolysis
reactions. Model studies with mono and dinuclear metal complexes have allowed us to
better understand the modes of activations that metal ions can provide and the coop-
erativity of metal ions in the hydrolysis reactions. Although much progress has been
made over the past decade, developing evermore-stable yet reactive metal complexes
for the sequence-specific hydrolysis of proteins and nucleic acids remains an impor-
tant challenge. Stereoselective hydrolysis of amides and esters and obtaining maxi-
mum catalytic turnover for the hydrolysis reactions are some of the other remaining
challenges.
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