Biomedical Engineering Reference
In-Depth Information
TaBlE 7.1:
Neuronal yield for eight channel microelectrode array
Electrode
1
2
3
4
5
6
7
8
Yield (neurons)
2
2
2
3
6
5
3
4
Noise floor
(µV, RMS)
4.1
5.0
5.3
4.4
5.2
3.8
3.7
4.3
Neuron amplitude
(µV, PtP)
20.1
23.3
32.6
26.1
114.7
90.4
31.4
45.1
13.2
15.5
24.7
18.3
56.8
52.3
13.4
29.7
14.2
34.6
35.7
11.7
21.0
21.3
21.0
16.0
18.8
13.8
17.4
SNR (dB)
13.8
13.4
15.8
15.5
26.9
27.6
18.6
20.4
10.2
9.9
13.4
12.4
20.8
22.8
11.2
16.8
10.2
16.5
19.5
10.0
13.8
12.2
14.8
11.4
11.2
11.2
10.5
large as 115 µV and as small as 13 µV are discriminated by the electrode and recording system. The
average RMS noise floor is 4 µV. Figure
7.5
shows recorded data from electrode number 6.
Acute electrophysiological recordings show excellent yield of recordable neurons and SNRs
ranging from 10 to 27 dB. The benefits of the microfabrication design allows for tailoring the elec-
trode geometry for neuronal structures of interest. Moreover, high channel count arrays can be con-
structed by layering the proposed design. The flexible cable additionally provides strain relief from
the fixed external connection and can be used to minimize tissue damage in chronic applications.
Additional studies on the reliability of the electrode array as a chronic recording device is needed to
