Biomedical Engineering Reference
In-Depth Information
A
PTMC-NH
2
PTMC-
b
-PBLG
BLG
THF/MeOH
H
2
/Pd
B
PTMC-
b
-PLGA
60
D
C
50
40
30
20
20° C, pH 7.4
37° C, pH 5.5
37° C, pH 7.4
45° C, pH 7.4
5° C, pH 7.4
10
0
0
200 nm
4
8
12
Time (hour)
16
20
24
Figure 15.3
(A) Synthesis of PTMC-
b
-PLGA. (B) Schematic representation of vesicle
obtained from the self-assembly of PTMC-
b
-PLGA in water. h e green part (deep color)
represents PTMC and the blue part (light color) expresses PLGA. (C) Transmission
electron microscopy (TEM) microimage of the DOX-loaded vesicle prepared at pH 10.5.
(D) Cumulative release of DOX loaded within PTMC-
b
-PLGA vesicle (
R
h
= 60 nm) in
various pH and temperature conditions. h e DOX-loaded vesicles were prepared at pH
10.5. Reproduced with permission from [52-54].
as potential drug delivery platforms, which benei ted from their tunable
chemical and three-dimensional physical structures, high stabilities, excel-
lent drug loading capabilities, and responsiveness to environmental fac-
tors, such as pH, redox, temperature and ionic strength [3, 66]. Among
them, the stimuli-responsive nanogels with nonfouling biocompatible
hydrophilic shells have attracted much attention ascribed to their excellent
dispersions in aqueous environment and stabilities in the complex
in vivo
circulatory system [23, 67, 68]. For malignancy therapy, various antitumor
drugs can be loaded into the restrictively stable nanogels and released as
