Biomedical Engineering Reference
In-Depth Information
Liposomal
drugs
Free drug
Reduce
irritation
Stratum
Corneum
Enhance drug
permeation
Prolong
resistance time
Reduce systemic
toxicity
Epidermis
Dermis
Blood
supply
Figure 14.2
Liposomal drug and free drug delivery compared.
that of drug suspension was 539.49% which suggested the use of developed
ramipril nanoemulsion for paediatric and geriatric patients [10].
Solid lipid nanoparticles are lipid-based submicron colloidal carriers.
h ey were initially designed as pharmaceutical an alternative to liposomes
and emulsions. In case of solid lipid nanoparticles, the drug is entrapped
in solid lipid matrix to produce lipid nanoparticles of size range 50-100nm
by using hot or cold high pressure homogenization technique [4]. h ey are
more stable than liposomes because of their rigid core consisting of hydro-
phobic lipids which are solid at room and body temperature, surrounded by
a monolayer of phospholipids. h ey can be stabilized by high level of sur-
factants. h ey are less toxic than polymeric nanoparticles because of ease of
biodegradation. Solid lipid nanoparticles have important advantages, such
as their physiological compounds and large scale production favoured their
feasibility thus avoiding organic solvents in the manufacturing process [11].
Nanosuspensions are poor water soluble drugs dispersed in aqueous
phase containing stabilizing agent [4]. Clofazimine, a riminophenazine
compound used for treating patients with
M. avium
infection and because
of its poor solubility the drug usage was restricted, now to overcome this
problem of solubility. It was formulated as a nanosuspension (385 nm) and
was administered to mice intravenously which has resulted in reduction of
bacterial loads in the liver, lungs, spleen of mice [12].
