Biomedical Engineering Reference
In-Depth Information
12
Prussian Blue and Analogues: Biosensing
Applications in Health Care
Salazar P
1,2,
*, Martín M
1,3
, O'Neill RD
4
, Lorenzo-Luis P
5
, Roche R
1,2
and González-Mora JL
1
1
Neurochemistry and Neuroimaging group, Faculty of Medicine, University
of La Laguna, Tenerife, Spain
2
Informática y Equipamiento Médico de Canarias S.A., Tenerife, Spain
3
Atlántica Biomédica S.L., Tenerife, Spain
4
UCD School of Chemistry and Chemical Biology, University
College Dublin, Ireland
5
Department of Inorganic Chemistry, Faculty of Chemistry, University of La
Laguna, Tenerife, Spain
Abstract
Prussian Blue (PB), Fe
4
[Fe(CN)
6
]
3
, belongs to a transition metal hexacyano-
metallate family. Its electrochemical properties were revealed in 1978 when Nef
reported the successful deposition of a thin layer on platinum foil. At er that,
numerous publications have appeared exploring its electrocatalytic properties and
its applications in biomedical science. During the last decade, a great number of
studies involving PB have appeared, using dif erent biosensor substrates and dif-
ferent oxidase enzymes. Together with the facile modii cation of the electrode sub-
strate and the low cost of production, this has led to an on-going replacement of
the more common enzymatic detection method involving horseradish peroxidase.
Its high electrocatalytic activity and low operating overpotential have contributed
to the diversii cation of its use in enzyme-based biosensors and immunosensors.
Based on these results, it is clear that PB and its analogues will have important
roles in the future development of biomedical devices for next generation health-
care strategies.
Keywords:
Prussian blue, biosensors, immunosensors, health care
