Biomedical Engineering Reference
In-Depth Information
than the relevant NIPs. However, the nano-sized MIP was better than the
micro-sized MIP for transportation of atenolol. Furthermore, the bulky
MIP was not proper atenolol carrier in the BLM, since its transportation
characteristic was similar to that of its relevant NIP. Moreover, the selectiv-
ity of the BLM containing dif erent kinds of the MIPs obeyed the order of
nano-MIP > micro-MIP > bulky MIP. h e nano-MIP was adopted as the
best atenolol carrier among the tested MIP-based carriers and then the ef ect
of dif erent factors on its transportation ei ciency was evaluated. A kinetic
model was proposed for the transportation of atenolol through the nano-
MIP based BLM. It was found that the extraction of atenolol from the source
to the membrane control the separation rate.
11.3.4 ImprintedNanogel
Cakir
et al.
, proposed a new approach for the synthesis of MIPs (synthetic
antibodies) as soluble nanogels with sizes close to the size of real antibodies
[90]. To imprint a molecular memory in particles consisting of only a few
polymer chains, an initiator carrying multiple iniferter moieties is used.
h is allows for the simultaneous initiation of several polymer chains, and
yields molecularly imprinted nanogels (17 nm, molecular weight (MW) =
97 kDa) with good ai nity and selectivity for the target
.
Molecularly imprinted hydrogel nanospheres as devices for the con-
trolled/sustained release of 5-l uororacil in biological l uids were synthe-
sized employing one-pot precipitation technique as the polymerization
method. MAA as a functional monomer and EGDMA as a cross-linker
were used in polymeric feed [91]. Morphological and hydrophilic prop-
erties were determined by scanning electron microscopy and water con-
tent measurement, and recognition and selectivity properties of spherical
molecularly imprinted polymers were compared with the spherical non-
imprinted polymers, both in organic (acetonitrile) and water media.
Finally,
in vitro
release studies were performed in plasma simulating l uids.
h e interactions between the template and the functional monomer
are a key to the formation of cavities in the imprinted nanogels with high
molecular recognition properties [92]. Nanogels with enzyme-like activity
for the Kemp elimination have been synthesized using 4-vinylpyridine as
the functional monomer and indole as the template. h e weak hydrogen
bond interaction in the complex is shown to be able to induce very distinc-
tive features in the cavities of the imprinted nanogels. h e percentage of
initiator used in the polymerisation, ranging from 1% to 3%, although it
does not have a substantial ef ect on the catalytic rate, reduces considerably
the imprinting ei ciency. h e alteration of the template/monomer ratio
