Biology Reference
In-Depth Information
FCGR2A
and
FCGR2B
genes (1q23; Warmerdam
et al
., 1993); the 5
end of the
FCGR2C
gene exhibits significant homology to the
FCGR2B
gene whilst its 3
end is homologous to the
FCGR2A
gene. Finally, two human ubiquitin genes rep-
resent the products of an in-frame fusion event between a ubiquitin gene and a
ribosomal protein gene encoding a protein of either 52 (
UBA52
; 19p13; Baker
and Board, 1991, 1992) or 76-80 (
UBA80
) amino acids in length (Lund
et al
.,
1985).
9.3.2 Internal methionines as evidence for ancient gene fusion events
Berman
et al
. (1994) demonstrated that some 20% of eukaryotic proteins are mul-
tiples of 123 ± 3 amino acids. This modular structure has been held to reflect
the combinatorial fusion of genes, initially of the same elementary size, during
07
09
23
14
25
06
22
20
04
26
08
19
02
05
03
11
24
15
12
27
21
10
13
Long-wave (
RCP
) gene
Middle-wave (
GCP
) gene
Hybrid gene
17
18
01
Figure 9.6.
Inferred visual pigment gene (
RCP
,
GCP
) arrangements in 26 individuals
with normal color vision ( redrawn from Neitz
et al
., 1995).
