Biology Reference
In-Depth Information
exon 2 spliced to an alternative acceptor site located 45 bp into exon 3, the
GH2
gene does not utilize this alternative splicing pathway. Three single base substitu-
tions located between the two alternative acceptor splice sites have been shown to
be both necessary and sufficient to define the
GH1
alternative splicing event
(Estes
et al
., 1990). One of these changes is thought to specify a lariat branchpoint
essential for alternative acceptor site usage whereas the other two bases may serve
to modulate the frequency with which the site is selected.
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