Biology Reference
In-Depth Information
DNA
Transcription
Duplication
RNA
DNA
Non-processed pseudogene
Processing
AAAAA
RNA
DNA
Reverse
transcription and
integration of
double-stranded
cDNA
Processed pseudogene
Figure 6.1.
Schematic diagram depicting the different mechanisms of pseudogene
formation.
Table 6.1.
Examples of human pseudogenes (
) generated by duplication
Pseudogene
Complete/partial
Comments
Reference
Cytochrome P450c21
Complete
Linked to
CYP21
Harada
et al
. (1987)
(6p21.3) gene
Amylase
Partial (lacks exons 1-3)
Linked to
AMY
gene
Groot
et al
. (1990)
cluster (1p21)
Apolipoprotein C1
Complete
Linked to
APOC1
Raisonnier (1991)
(19q13.2) gene
Tyrosinase
Partial (exons 4 and 5
11p11.2-cen. Unlinked
Giebel
et al
. (1991)
and non-coding )
to
TYR
gene (11q14-
q21). Not transcribed.
Dopamine D5 receptor
Complete (intronless
ψ
on chromosomes 1
Marchese
et al
. (1995)
(2)
derived from intronless
and 2. Unlinked to
(1995)
gene)
DRD5
gene (4p15-p16).
Olfactory receptor
Complete
Linked to olfactory
Crowe
et al
. (1996)
receptor gene cluster on
chromosome 17.
Transcribed.
Histone H2B
Complete
Linked to other histone
Albig
et al
. (1997)
genes (1q21-q23).
Keratin K14
Complete
Unclear if linked to
Savtchenko
et al
.
KRT14
gene at 17q12-q21
(1988)
.
Fibroblast growth
Partial (exon 2,
Transcribed. Dispersed.
Kelley
et al
. (1992)
factor (16?)
intron 2,
Unlinked to
FGF7
gene
exon 3 and 3
′
UTR)
(15q15-q21).
XG blood group
Partial (exons 1, 2A, 2B,
Yq11.21.
XG
gene
Weller
et al
. (1995)
3)
maps to pseudo-
autosomal boundary
region, Xp22-pter
Transcribed.
