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(a)
C
C A — 210
A G
A T
C T
G=C
G=C
T=A
T=A
T=A
AGGAG AGGCT
|
220
C
C A — 210
A G
A T
C T
G=C
G=C
T=A
T=A
T=A
AGGAG AGGCT
|
220
T
A
200 — G
5'
3'
5'
3'
(b)
.19bp.
. .
. .
A T
440-C T
G A
.19bp.
. .
. .
A T
440-C T
C A
T=A
A=T
A=T- -410
A=T
T=A
*T=A
*G=C
A=T
-450-A=T
AAGTT TTCTG
|
-400
T=A
A=T
A=T- -410
A=T
T=A
A A
A C
A=T
-450-A=T
AAGTT TTCTG
|
-400
5'
3'
5'
3'
(c)
***** * * ** * * ****************
TAATTAAATTAA-ATGTCAATAGCTTTTAAACTTAGATTTTAGTT
| | | |
-450 -440 -430 -420
5'
3'
**************** ****************
TAATTAAACTTAGATTTTAATAGCTTTTAAACTTAGATTTTAGTT
| | | |
-450 -440 -430 -420
5'
3'
Figure 4.27. Evolution of the human α -interferon gene cluster; the role of template-
mediated mutational changes (redrawn from Golding and Glickman, 1985). (a) An
inverted repeat may have formed a template for the deletion of a GAT codon in the
IFNA2 gene. (b) An inverted repeat may have formed a template for an AA to GT change
within the 5 flanking region of the interferon “
9” gene. (c) A direct repeat may have
directed five changes in the 5 flanking region of the IFNA10 gene. The 16 bp repeat is
marked by asterisks. The putative ancestral sequence is shown above, the descendent
sequence below.
 
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