Biology Reference
In-Depth Information
Duplication and differentiation
into embryonic
and adult
MARSUPIAL
THERIAN ANCESTOR
Insertion of LINE beween ε and γ
EUTHERIAN ANCESTOR
PRIMATE
Conversion of δ by β
Inactivation of
M
M
OPOSSUM
RODENT
Loss of
LAGOMORPH
Loss of
η
Conversion of δ
by β
Fusion of ψη
with δ
Inactivation of δ
α - β duplication
Inactivation of δ
ψη −δ
Duplication
Fusion
Duplication
RABBIT
LEMUR
Conversion
Conversion of δ by β
Loss of ψη exon 3
Replacement of
y
h0
h1
h2
h3
1
2
ψη −δ
intergenic region by LINES
MOUSE
ARTIODACTYL
Loss of γ
Conversion of
γ duplication
Conversion between γ
''s
by
Fetal recruitment of
GALAGO
Inactivation of
Conversion of
by
Conversion of δ
by β
TARSIER
Triplication of locus
Fetal recruitment of
F
Juvenile recruitment of β
C
z
I
II
x
C
III
IV
A
V
VI
y
F
G
A
HUMAN
GOAT
Figure 4.13 . Evolution of the β -globin gene cluster in mammals (redrawn from Tagle et al ., 1992). Genes represented by boxes composed of two
patterns denote the occurrence of specific recombinational events (gene conversions or crossovers). The insertion of a LINE element between the ε
and γ
globin genes is shown as an open triangle. The solid triangles denote orthology verified by sequence comparisons.
 
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