A Prototype of Translational Informatics in Action - Translational Informatics: Realizing the Promise of Knowledge-Driven Healthcare - page 29

Discussion Points

￿ What are the major actors and activities impacted by the vision of Translational
Informatics? How are they interrelated?
￿ What barriers exist to achieving this vision and what are their origins?
￿ How do the frameworks related to the creation of “learning healthcare systems”
that exhibit an “evidence generating medicine” paradigm impact or infl uence the
Translational Informatics and knowledge-driven healthcare vision?

References

1. Payne PR, Embi PJ, Sen CK. Translational informatics: enabling high throughput research
paradigms. Physiol Genomics. 2009;39:131-40. Epub Sept 2009.
2. Payne PR, Johnson SB, Starren JB, Tilson HH, Dowdy D. Breaking the translational barriers:
the value of integrating biomedical informatics and translational research. J Investig Med.
2005;53(4):192-200. PubMed PMID: 15974245, Epub 2005/06/25. eng.
3. Ahn AC, Tewari M, Poon CS, Phillips RS. The limits of reductionism in medicine: could sys-
tems biology offer an alternative? PLoS Med. 2006;3(6):709-13.
4. Auffray C, Chen Z, Hood L. Systems medicine: the future of medical genomics and health-
care. Genome Med. 2009;1(1):2.
5. Schadt EE, Bjorkegren JL. Network-enabled wisdom in biology, medicine, and health care.
Sci Transl Med. 2012;4(115):115rv1.
6. Colon cancer: colon adenocarcionma. In: Pathologists CoA, editor. College of American
Pathologists; 2011. http://www.cap.org/apps/docs/reference/myBiopsy/ColonAdenocarcinoma.pdf

7. Fearnhead NS, Wilding JL, Winner B, Tonks S, Bartlett S, Bicknell DC, et al. Multiple rare
variants in different genes account for multifactorial inherited susceptibility to colorectal ade-
nomas. Proc Natl Acad Sci U S A. 2004;101(45):15992-7.
8. Friedman CP, Wong AK, Blumenthal D. Achieving a nationwide learning health system. Sci
Transl Med. 2010;2((57):57cm29.
9. Embi PJ, Payne PR. Evidence generating medicine: redefi ning the research-practice relation-
ship to complete the evidence cycle. Med Care. 2013;51:S87-91.
10. Hood L, Friend SH. Predictive, personalized, preventive, participatory (P4) cancer medicine.
Nat Rev Clin Onc. 2010;8:184-7.

Additional Reading

Ahn AC, Tewari M, Poon CS, Phillips RS. The limits of reductionism in medicine: could systems
biology offer an alternative? PLoS Med. 2006;3(6):709-13.
Auffray C, Chen Z, Hood L. Systems medicine: the future of medical genomics and healthcare.
Genome Med. 2009;1(1):2.
Embi PJ, Payne PR. Evidence generating medicine: redefi ning the research-practice relationship to
complete the evidence cycle. Med Care. 2013;51:S87-91.
Friedman CP, Wong AK, Blumenthal D. Achieving a nationwide learning health system. Sci
Transl Med. 2010;2(57):57cm29.
Hood L, Friend SH. Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat
Rev Clin Onc. 2010;8:184-7.
Payne PR, Embi PJ, Sen CK. Translational informatics: enabling high throughput research para-
digms. Physiol Genomics. 2009;39:131-40. Epub Sept 2009.
Schadt EE, Bjorkegren JL. Network-enabled wisdom in biology, medicine, and health care. Sci
Transl Med. 2012;4(115):115rv1.