Information Technology Reference
In-Depth Information
Chapter 2
A Prototype of Translational
Informatics in Action
Philip R. O. Payne
By the End of this Chapter, Readers Should Be Able To
￿ Understand the multiple types and levels of stakeholders, and their respective
activities that can and should be impacted by the Translational Informatics
paradigm;
￿ Describe an exemplary clinical scenario that illustrates the scope and impact of
Translational Informatics on the delivery of knowledge driven healthcare; and
￿ Apply the preceding context to subsequent chapters that explore various dimen-
sions of the tight coupling of Biomedical Informatics and the domains of bio-
medical research and clinical care delivery in order to achieve the vision of
Translational Informatics.
2.1
Introduction
As was presented in Chap. 1 , the vision for Translational Informatics (TI) is predi-
cated on three critical and synergistic dimensions, namely:
1. The promise of translational science, particularly as applied to biomedicine [ 1 , 2 ] ;
2. An emergent trend away from reductionism and towards systems thinking [ 3 - 5 ];
and
3. The formalization of a central dogma for the broad domain of Biomedical
Informatics.
These dimensions have broad ranging and signifi cant impacts on a variety
of actors and their activities that serve to make up the biomedical research and
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