Chemistry Reference
In-Depth Information
HS
Traut's reagent
+
(b)
O
O
O
O
N
I
N
O
O
O
O
NH
2
NH
2
+
SIA
N-succinimidyl
iodoacetate
Cy5.5
NHS ester
(c)
Polyethylene glycol
Iron oxide
nanoparticle
Chlorotoxin
O
S
O
Cy5.5
ScheMe 16.8
Covalent attachment of CTX to nanoparticle surface using a cross-linking strategy. Reproduced from Ref. [47] with
permission from the American Chemical Society.
(a)
In vivo
MR images
Pre-injection
Post-injection
Std
Std
60
50
40
30
60
50
40
30
20
10
20
10
Pre-injection R2 map
Post-injection R2 map
(b)
Ex vivo
NIRF images
Post-injection
Non-injected
6.0
4.0
2.0
fIGure 16.12
(a) MRI of the mouse bearing a 9 L tumour pre- and post-injection (48 h) of the CTX-Cy5.5 nanoparticles. Heterogeneous
accumulation of the nanoparticles is observed by negative contrast enhancement and changes in the R
2
measurements in the region of
interest. (b)
Ex vivo
NIRF image of xenograft tumours acquired from a control mouse (left) and the mouse injected with CTX-Cy5.5
nanoparticles (right). Reprinted with permission from Ref. [47]. Copyright 2010 American Chemical Society. (
See insert for colour
representation of the figure.)
)
