Chemistry Reference
In-Depth Information
-
N
Cu
2+
-
N
HN
NH
HN
O
O
O
O
-
-
NH
N
N
O
O
Gd
3+
Gd
3+
Na
+
Na
+
N
N
-
-
-
-
O
O
O
N
N
O
O
O
-
-
(b)
(c)
0 h
1 h
4 h
24 h
FIgure 15.9
Dual-modality MRI/optical imaging with gadophrin-2. (a) Chemical structure of gadophrin-2. (b) Optical images and
MRI images (c) of a mouse before and after injection of gadophrin-2-labelled hematopoietic cells, which showed a progressive cell
accumulation in various organs (e.g., the lung). adapted with permission from Ref. [121]. (
See insert for colour representation of the figure.)
)
O
O
O
O
N
N
N
Gd
3+
O
O
O
O
NH
O
NH
S
BN Cy5.5
FIgure 15.10
Chemical structure of gd-TTDa-NP-BN-Cy5.5, which was used for MRI/optical imaging of prostate cancer in tumour-
bearing mice.
