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Cl
HO
NH
OH
OH
H
3
C
O
CH
3
O
CH
2
OH
O
HO
NH
2
O
Cl
O
O
H
3
C
O
CH
3
Cl
O
OH
O
O
H
N
H
N
H
N
N
H
NH
CH
3
O
H
H
H
H
O
NH
H
O
O
O
H
NH
2
HO
2
C
OH
OH
HO
OH
OH
H
N
O
CH
2
OH
O
O
O
O
Cl
HO
O
O
H
N
H
N
H
N
H
N
H
NH
O
H
H
H
O
O
CH
3
Cl
O
H
N
NH
H
HO
N
O
O
O
HO
OH
OH
OH
HO
O
OH
OH
Scheme 2-11. Structures of LY-333328 (oritavancin) and dalbavancin, which are currently in
clinical phase trials.
the amino group of 4-epi-vancosamine with a N
0
-p-(p-chlorobiphenyl)benzyl-
residue. The antibacterial activity spectrum of LY-333328 has been investigated
in various studies, which are summarized in a review article.
159
In analogy to the
suggested membrane insertion mechanism of teicoplanin,
28
also for of the N-alkyl
glycopeptide derivatives, a similar mechanism is assumed. This mechanism had
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