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OH
OH
A. balhimycina
wild-type
HO
(a)
Cl / Br salts
X
1
, X
2
= Cl / Br
CH
2
OH
O
F
O
O
NH
2
OH
X
1
O
O
HO
H
3
C
O
CH
3
COOH
X
2
A. balhimycina
β-hydroxytyrosine
mutant
(b)
O
H
2
N
OH
O
O
H
N
H
N
H
N
X
1
, X
2
= F
N
H
O
NH
CH
3
H
H
H
2
N
COOH
H
H
O
O
NH
H
NH
O
O
H
A. balhimycina
dihydroxyphenyl-
glycine mutant
NH
2
HO
2
C
R
1
O
R
2
R
1
= H, CH
3
R
2
= H, OH, OCH
3
OR
1
R
2
OH
Scheme 2-10. Biotechnological generation of novel type I glycopeptide aglycones modified at AA2/AA6
and AA7 with (a) media supplementation
126
and (b) mutasynthesis of modified amino acids.
98,99
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