Chemistry Reference
In-Depth Information
C-
O
-D-ring
Cl
Cl
OH
Cl
OH
HO
HO
HO
O
NRPS
peptide assembly
OH
Cl
OH
OH
HO
OxyB
O
O
O
O
H
N
H
N
H
N
H
N
H
N
H
N
H
H
N
H
HOOC
N
H
N
H
NH
N
H
NH
HOOC
H
H
H
H
H
H
H
O
O
O
O
NH
2
H
O
NH
2
H
O
O
O
O
O
NH
2
NH
2
HO
OH
HO
OH
OH
OH
OH
D-
O
-E-ring
Cl
O
O
OH
Cl
O
O
Cl
HO
OH
OxyA
O
OxyC
O
Cl
OH
H
N
HO
H
N
H
N
O
O
H
N
H
N
H
N
N
H
NH
O
H
N
H
H
H
H
H
N
H
NH
O
HOOC
O
NH
2
H
H
H
H
NH
H
O
O
O
O
NH
2
H
H
O
O
O
NH
2
HO
2
C
NH
2
OH
HO
OH
OH
HO
OH
AB-ring
Scheme 2-6. The order of the side-chain cyclization reactions performed by three P450-dependent
monooxygenases (OxyA/B/C).
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