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In-Depth Information
10
RECENT PROGRESS ON THE
CHEMICAL SYNTHESIS OF
ANNONACEOUS ACETOGENINS
AND THEIR STRUCTURALLY
MODIFIED MIMICS
T
AI
-S
HAN
H
U
,Y
U
-L
IN
W
U
,
AND
Z
HU
-J
UN
Y
AO
State Key Laboratory of Bioorganic and Natural Products Chemistry,
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
10.1
INTRODUCTION
Annonaceous acetogenins are a large family of natural polyketides, whose number
now reaches 400. In the past 15 years, it was recognized as an attractive and impor-
tant area of phytochemistry and synthetic chemistry. For example, the Journal of
Natural Products chose acetogenin as its cover for the first six issues in 1999.
The first acetogenin, uvaricin, was isolated and characterized in 1982 by Jolad
et al.,
1
from the plant Uvaria acuminate. Most annonaceous acetogenins have been
reported to exhibit a variety of bioactivities, including anticancer activities and
cytotoxicities against various cancer cells. A few review articles
2-12
were published
in key peer-reviewed journals in recent years, covering studies on the phytochem-
istry, structural elucidation, bioactivity, and mechanism. Herein, we will conduct an
overview on the progress of the total syntheses and related studies of the naturally
occurring acetogenins since 1998.
So far, annonaceous acetogenins have only been found in various species of
Annonaceae. Typical acetogenins present several unique structural characteristics
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