Chemistry Reference
In-Depth Information
9.5
CONCLUSIONS
In a decade of extensive research, great progress has been achieved in the discovery
of potential anti-HIV agents. Plants are a great reservoir of biologically active com-
pounds and can provide good leads that are structurally unique or have new
mechanisms of action. Our anti-HIV research program began from natural products
and led to the discovery of potent khellactone analogs and related compounds,
dibenzocyclooctadiene lignans and derived biphenyl components, and BA deriva-
tives. In the whole process of drug discovery and development, we begin with
bioactivity-directed isolation, followed by rational design-based structural modifi-
cation and SAR analyses. Our goals include increasing the activity profile, over-
coming absorption, distribution, metabolism, excretion and toxicity problems,
generating new lead compounds, and finally entering clinical trials.
ACKNOWLEDGMENTS
This investigation entitled ''Anti-AIDS Agents 63'' was supported by Grant AI-
33066 from the National Institute of Allergies and Infectious Diseases awarded
to K. H. Lee. We wish to express our sincerest thanks to Dr. Susan L. Morris-
Natschke for her experienced editing. Also, we acknowledge the contributions
from our collaborators, most of whom are cited in the references.
92-94
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