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TABLE 9-11. Structures and Activity of 3-O-Acyl-Betulinc
Acid Derivatives (262-275)
69
H
H
OH
OH
H
H
O
O
H
H
RO
RO
H
H
262-266
267-275
R
Compound
EC
50
(mM)
TI
Compound
EC
50
(mM)
TI
H
182
1.4
9.3
186
0.9
14
O
262
2.7
6.7
267
0.56
13.8
COOH
O
263
<
0.00035
>
20000
268
<
0.00035
>
14000
COOH
(DSB)
O
264
0.0023
1974
269
0.0057
1017
COOH
O
265
0.01
1172
270
0.0056
2344
O
COOH
O
266
0.044
292
271
0.9
9
COOH
O
272
1.8
7.5
COOH
O
273
0.5
2
O
O
O
274
1.5
56
O
275
NS
The activity was screened in acutely infected H9 lymphocytes.
NS, no suppression at testing concentration.
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