Chemistry Reference
In-Depth Information
162. Gu, H. M.; Lu, B. F.; Qu, Z. Q. Antimalarial activities of 25 derivatives of artemisinin against
chloroquine-resistant Plasmodium berghei. Acta Pharmacol. Sin., 1980, 1: 48-50.
163. Yu, P. L.; Chen, Y. X.; Li, Y.; Ji, R. Y. Studies on analogs of artemisinin. IV. Synthesis of
derivatives of qinghaosu containing halogen, nitrogen and sulfur heteroatoms. Chin.
Pharmaceu. Bull., 1980, 15: 44; Acta Pharmaceu. Sin., 1985, 20: 357-365.
164. Pu, Y. M.; Torok, D. S.; Ziffer, H.; Pan, X.-Q.; Meshnick, S. R. Synthesis and
antimalarial activities of several fluorinated artemisinin derivatives. J. Med. Chem.,
1995, 38: 4120-4124.
165. Abouabdellah, A.; B ´ gu ´ , J.-P.; Bonnet-Delpon, D.; Gantier, J. C.; Truong Thi Thanh,
N.; Truong, D. T. Synthesis and in vivo antimalarial activity of 12 a-trifluoromethylhydro-
artemisinin. Bioorg. Med. Chem. Lett., 1996, 6: 2717-2720.
166. Nga, T. T. T.; M ´ nage, C.; B ´ gu ´ , J.-P.; Bonnet-Delpon, D.; Gantier, J.-C.; Pradines, B.;
Doury, J.-C.; Thac, T. Synthesis and antimalarial activities of fluoroalkyl derivatives of
dihydroartemisinin. J. Med. Chem., 1998, 41: 4101-4108.
167. Magueur, G.; Crousse, B.; Charneau, S.; Grellier, P.; B´gu´, J.-P.; Bonnet-Delpon, D.
Fluoroartemisinin: Trifluoromethyl analogues of artemether and artesunate. J. Med.
Chem., 2004, 47: 2694-2699.
168. Venugopalan, B.; Karnik, P. J.; Bapat, C. P.; Chatterjee, D. K.; Iyer, N.; Lepcha, D.
Antimalarial activity of new ethers and thioethers of dihydroartemisinin. Eur. J. Med.
Chem., 1995, 30: 697-706.
169. Haynes, R. K.; Chan, H. W.; Cheung, M. K.;. Lam, W. L.; Soo, M. K.; Tsang, H. W.;
Voerste, A.; Williams, I. D. C-10 Ester and ether derivatives of dihydroartemisinin-10a
artesunate, preparation of authentic 10-b artesunate, and of other ester and ether
derivatives bearing potential aromatic intercalating groups at C-10. Eur. J. Org. Chem.,
2002, 1: 113-132.
170. Liang, J.; Li, Y. Synthesis of the aryl ether derivatives of artemisinin. Chinese J. Med.
Chem., 1996, 6: 22-25.
171. O'Neill, P. M.; Miller, A.; Bishop, L. P. D.; Hindley, S.; Maggs, J. L.; Ward, S. A.;
Roberts, S. M.; Scheinmann, F.; Stachulski, A. V.; Posner, G. H.; Park, B. K. Synthesis,
antimalarial activity, biomimetic iron(II) chemistry, and in-vivo metabolism of novel,
potent C-10-phenoxy derivatives of dihydroartemisinin. J. Med. Chem., 2001, 44: 58-68.
172. Yang, Y. H.; Li, Y.; Shi, Y. L.; Yang, J. D.; Wu, B. A. Artemisinin derivatives with 12-
aniline substitution: Synthesis and antimalarial activity. Bioorg. Med. Chem. Lett., 1995,
5: 1791-1794.
173. Li, Y.; Liao, X. B. CN Patent: ZL 99,124,012.
174. Jung, M.; Bustos, D. A.; El-Sohly, H. N.; McChesney, J. D. A concise and stereoselective
synthesis of ( þ )-12-n-butyldeoxoartemisinin. Synlett., 1990, 743-744.
175. Jung, M.; Yu, D. Y.; Bustos, D.; El-Sohly, H. N.; McChesney, J. D. A concise synthesis of 12-
(3 0 -hydroxy-n-propyl)-deoxoartemisinin. Bioorg. Med. Chem. Lett., 1991, 1: 741-744.
176. Haynes, R. K.; Vonwiller, S. C. Effecient preparation of novel qinghaosu(artemisinin)
derivatives: Conversion of qinghaosu (artemisinic) acid into deoxoqinghaosu derivatives
and 5-carba-4-deoxoartesunic acid. Synlett., 1992, 481-483.
177. Pu, Y. M.; Ziffer, H. Synthesis and antimalarial activities of 12b-allyldeoxoartemisinin
and its derivatives. J. Med. Chem., 1995, 38: 613-616.
178. Ma, J. Y.; Katz, E.; Ziffer, H. A new synthetic route to 10-beta-alkyl deoxoartemisinins.
Tetrahedron Lett., 1999, 40: 8543-8545.
Search WWH ::




Custom Search