THE OVERVIEW OF STUDIES ON HUPERZINE A: A NATURAL DRUG FOR THE TREATMENT OF ALZHEIMER’S DISEASE - Medicinal Chemistry of Bioactive Natural Products - page 182

149. Xu, Y. C.; Shen, J. H.; Luo, X. M.; Silman, I.; Sussman, J. L.; Chen, K. X.; Jiang, H. L. How
does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered
molecular dynamics simulations. J. Am. Chem. Soc., 2003, 125(37): 11340-11349.
150. Kaur, J.; Zhang, M. Q. Molecular modelling and QSAR of reversible acetylcholinester-
ase inhibitors. Curr. Med. Chem., 2000, 7(3): 273-294.
151. Camps, P.; Cusack, B.; Mallender, W. D.; El Achab, R.; Morral, J.; Munoz-Torrero, D.;
Rosenberry, T. L. Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that
is of interest for treatment of Alzheimer's disease. Mol. Pharmacol., 2000, 57(2):
409-417.
152. Camps, P.; El Achab, R.; Morral, J.; Munoz-Torrero, D.; Badia, A.; Banos, J. E.; Vivas,
N. M.; Barril, X.; Orozco, M.; Luque, F. J. New tacrine-huperzine A hybrids (huprines):
highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of
Alzheimer's disease. J. Med. Chem., 2000, 43(24): 4657-4666.
153. Camps, P.; Gomez, E.; Munoz-Torrero, D.; Arno, M. On the regioselectivity of
the Friedlander reaction leading to huprines: stereospecific acid-promoted isomerization
of syn-huprines to their anti-regioisomers. Tetrahedron-Asymmetry, 2001, 12(20):
2909-2914.
154. Ros, E.; Aleu, J.; De Aranda, I. G.; Munoz-Torrero, D.; Camps, P.; Badia, A.; Marsal, J.;
Solsona, C. The pharmacology of novel acetylcholinesterase inhibitors ( )-huprines Y
and X on the Torpedo electric organ. Eur. J. Pharmacol., 2001, 421(2): 77-84.
155. Camps, P.; Gomez, E.; Munoz-Torrero, D.; Badia, A.; Vivas, N. M.; Barril, X.; Orozco,
M.; Luque, F. J. Synthesis in vitro pharmacology and molecular modeling of syn-
huprines as acetylcholinesterase inhibitors. J. Med. Chem., 2001, 44(26): 4733-4736.
156. Carlier, P. R.; Han, Y. F.; Chow, E. S. H.; Li, C. P. L.; Wang, H.; Lieu, T. X.; Wong, H. S.;
Pang, Y. P. Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual
binding site hypothesis. Bioorg. Med. Chem., 1999, 7(2): 351-357.
157. Harel, M.; Schalk, I.; Ehret-Sabatier, L.; Bouet, F.; Goeldner, M.; Hirth, C.; Axelsen,
P. H.; Silman, I.; Sussman, J. L. Quaternary ligand binding to aromatic residues in the
active-site gorge of acetylcholinesterase. P. Natl. Acad. Sci. USA, 1993, 90(19): 9031-
9035.
158. Dvir, H.; Wong, D. M.; Harel, M.; Barril, X.; Orozco, M.; Luque, F. J.; Munoz-Torrero,
D.; Camps, P.; Rosenberry, T. L.; Silman, I.; Sussman, J. L. 3D structure of Torpedo
californica acetylcholinesterase complexed with huprine X at 2.1 angstrom resolution:
kinetic and molecular dynamic correlates. Biochemistry, 2002, 41(9): 2970-2981.
159. Felder, C. E.; Harel, M.; Silman, I.; Sussman, J. L. Structure of a complex of the potent
and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase. Acta
Crystallogr. D Biol. Crystallogr., 2002, 58: 1765-1771.
160. Wong, D. M.; Greenblatt, H. M.; Dvir, H.; Carlier, P. R.; Han, Y. F.; Pang, Y. P.; Silman,
I.; Sussman, J. L. Acetylcholinesterase complexed with bivalent ligands related to
huperzine A: experimental evidence for species-dependent protein-ligand complemen-
tarity. J. Am. Chem. Soc., 2003, 125(2): 363-373.
161. Dvir, H.; Jiang, H. L.; Wong, D. M.; Harel, M.; Chetrit, M.; He, X. C.; Jin, G. Y.; Yu,
G. L.; Tang, X. C.; Silman, I.; Bai, D. L.; Sussman, J. L. X-ray structures of Torpedo
californica acetylcholinesterase complexed with ( þ )-huperzine A and ( )-huperzine B:
structural evidence for an active site rearrangement. Biochemistry, 2002, 41(35):
10810-10818.