Biomedical Engineering Reference
In-Depth Information
ORIGIN OF CELLS
& SIGNALS
STAGES OF FRACTURE REPAIR
Biological Processes
Initial Injury
Muscle
D.
Inflammation
Marrow response
Hematoma
MSC recruitment
Cortical Bone
E.
A.
Endochondral Formation
Cartilage formation
Periosteal Response
ECB
Vascular ingrowth
Intramembranous bone
Formation
F.
IMB
Primary Bone Formation
Bone cell recruitment
Chondrocyte apoptosis
Matrix proteolysis
Osteoclast* recruitment
Endochondral neovascularization
B.
G.
Secondary Bone
Secondary Bone Formation
Establishment of marrow
Osteoclast remodeling
Coupled osteoblast recruitment
C.
