Biomedical Engineering Reference
In-Depth Information
6.4 Summary
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Scaffold design is an intricate process that must
be custom tailored for different applications.
Scaffolds must induce cell growth, support cell
adhesion and proliferation, and provide the
mechanical stability needed in different sites.
Synthetic polymers can be readily modifi ed so
that their properties are appropriate for bone
tissue engineering. Their properties are modu-
lated by the fabrication method: both conven-
tional and rapid-prototyping techniques have
produced viable bone tissue scaffolds. Funda-
mental design parameters depend on the needs
of the regenerated tissue and include polymer
assembly, curing methods, surface properties,
macrostructure, mechanical properties, bio-
degradation, and biocompatibility, both of the
scaffold per se and its degradation products.
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