Chemistry Reference
In-Depth Information
10
Amidines and Guanidines in Natural
Products and Medicines
Takuya Kumamoto
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi,
Inage, Chiba 263-8522, Japan
10.1
Introduction
The excellent reviews of Berlinck [1-5] have surveyed a great number of guanidine-type
natural products. In addition, some guanidine-derivedmarine alkaloids have been reviewed
by Kobayashi and Ishibashi [6,7]. Also, a recent book gave accounts of marine alkaloids
including the phakellins, palau
amines and oroidin-like dimers derived frombromopyrroles
and polyketide-derived polycyclic guanidine alkaloids [8].
Some of the medicines that contain amidines and/or guanidines have been reviewed,
too [9].
In this chapter, natural products and medicines bearing guanidine and amidine functions
are discussed. The topics covered include the amidine and guanidine natural products for
which isolation, total synthesis and/or structural revision have recently been reported, as
well as medicines, with the focus on activity, stability and mode-of-action.
10.2 Natural Amidine Derivatives
In this section, natural products with the amidine moiety are examined. They have mostly
been isolated as fermentation products of actinomycete. For example,
isolation of
