Chemistry Reference
In-Depth Information
CO
2
Me
CO
2
Me
HgCl
2
Me
Me
H
H
O
OH
HCl-CH
3
CN
SPh
Me
Me
OMe
Me
Me
CHO
SPr
199
benzene
75 °C
DBU (
1
)
99%
CO
2
H
CO
2
Me
Me
H
Me
H
O
O
1. HO(CH
2
)
2
OH
PTS, 89%
2. NaOH, MeOH
then HCl, 87%
Me
Me
Me
Me
CHO
CHO
scabronine G-ME (
200
)
(-)-scabronine G (
201
)
Scheme 7.46
Synthesis of (
)-scabronine G (201)
O
O
O
O
O
O
Me
Me
Me
Me
Me
Me
DBN (
2
)
h
ν
, O
2
O
O
23 °C
95% (2 steps)
Me
Me
Me
Me
Me
Me
202
204
203
Me
O
OH
Me
Me
O
OH
OAc
H
Me
Me
OH
folskolin (
205
)
Scheme 7.47
Synthesis of folskolin (205)
