Chemistry Reference
In-Depth Information
t
BuO
2
C
O
O
H
t
BuO
2
C
CO
2
t
Bu
Barton's base (
5
)
O
B
CD
O
O
O
76%
H
OO
5.9 : 1
CO
2
t
Bu
Me
Me
Me
Me
35
36
2. AcOH, H
2
O
air, 70%
1. KOH, BnBr, 78%
O
Me
O
N
O
OH
t
BuO
2
C
O
F
A
O
OH
MeO
1. RuCl
3
, NaIO
4
64%
O
O
O
A
BnO
2
C
BnO
2
C
B
O
C
DE
B
O
C
D
O
OH
2. TFA
26%
O
O
HO
O
O
O
Me
38
37
lactonamycin (
39
)
OH
Scheme 7.6
Synthesis of A-D ring system for lactonamycin (39)
