Chemistry Reference
In-Depth Information
FIGURE 18.13
Thyroid hormones and their side products diiodotyrosine (DIT) and monoiodotyrosine (MIT) formed during their
biosynthesis.
the preceding iodination reaction. Ultimately, approximately seven monoiodotyrosines (MIT), six diiodotyrosines
(DIT), and one T4 are formed per thyroglobulin molecule. Some thyroglobulin molecules also contain one T3.
When thyroid cells are activated by a signal such as thyroid-stimulating hormone, thyroglobulin is taken up from
the colloid by endocytosis and hydrolysed to release T4/T3 into the plasma (
Figure 18.14
). T4 can be considered
FIGURE 18.14
Iodide uptake, transport, metabolism, and salvage in thyroid follicular cells.
(Adapted from
Rokita, Adler, McTamney, &
Watson, 2010
.)
