Chemistry Reference
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FIGURE 14.10
Structural insight into laccases from X-ray crystallography. (a) A ribbon model of the X-ray crystal structure from T. ver-
sicolor Lac1 (PDB 1kya) with the coppers (orange circles) labeled by type and the organic substrate-binding cleft highlighted in red. (b)A
comparison of the architecture and sequence conservation between laccases from (top) T. versicolor Lcc1 (axial Phe in orange, PDB 1kya),
(middle) Rigidoporus microporous laccase (axial Leu in orange, PDB 1v10), (bottom) B. subtilis CotA (axial Met in orange, PDB 1gsk).
Coloured residue codes in the sequence alignment comprise the coordination spheres of the coppers; those around the type 1 copper are in
italics. (From
Rodgers et al., 2009
.
Copyright 2007, with permission from Elsevier.)
