Chemistry Reference
In-Depth Information
FIGURE 12.21
DNA and RNA recognition by the fifth zinc finger of TFIIIA. (a) The zinc finger recognises bases in the major groove of
5S rRNA promoter DNA (b) The finger recognises the phosphate groups of 5S rRNA.
(From
Hall, 2005
.
Copyright 2005 with permission
from Elsevier.)
interactions with bases of the DNA (for example, Leu 148 with a thymine residue of the DNA, in the RNA
interactions there are no direct interactions with the bases, and the interactions are essentially with the phosphate
groups of the 5S rRNA). Some residues in finger 5, such as Ser 150, Lys 144, Arg 154, and His 155 bind to both
RNA and DNA, but to different sites in each case. This is in marked contrast to the zinc finger 4 in which a His
binds directly to a guanosine and possible also to a second guanosine, and finger 6 in which a Trp stacks onto an
adenosine.
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