Chemistry Reference
In-Depth Information
R
R
O
H
H
H
H
C
H
+
C
C
NH
2
HO
O
Zn
II
Zn
II
N
+
Cys
Cys
Cys
Cys
His
His
C
H
NAD
+
H
2
O
RCH
2
OH
R
O
H
H
C
C
NH
2
OH
2
O
H
Zn
II
Zn
II
N
+
Cys
Cys
Cys
Cys
RCHO
H
2
O
His
His
C
H
LADH
NADH
FIGURE 12.10
The essential features of the catalytic cycle of liver alcohol dehydrogenase.
(Adapted from
Parkin, 2004
.)
H
pro-R
C
OH
H
pro-S
CH
3
Enzyme
FIGURE 12.11
Specific attachment of a prochiral centre to an enzyme-binding site enables the enzyme to distinguish between prochiral
methylene protons in ethanol.
(Adapted from Voet & Voet, 2004.)
