Chemistry Reference
In-Depth Information
FIGURE 12.8
Catalytic mechanism of MMPs. Scheme for the cleavage mechanism proposed for MMPs, with the catalytic zinc ion as a sphere and hydrogen bonds as dashed
lines. The three histidine ligands are represented by sticks. One conceivable alternative is that the second proton is transferred directly from the gem-diolate to the leaving amine in II
and not via the general base/acid glutamate. This proton transfer could hypothetically occur before or after scissile-bond cleavage.
(Adapted from
Tallant et al., 2010
.)
