Chemistry Reference
In-Depth Information
(a)
Intra-cellular
*
V
R F T S
*
TM11
I
K
L
TM12
H
*
E A N
I
S
H
S
R
TM4
I
TM10
*
TM5
TM9
TM2
TM6
T
R
V
I
F
T
P
V
TM7
COOH
TM3
*
F
TM8
H
Y
K
I
*
447
NH2
TM1
A
N
K
I
G
G
F
I
P
*
436
D
I
G
248
N
Q
A
L
L
P
M
F
F
505
253
A E
P
F
Y
L
374
D
R
G
V
I
N
R
I
L
G
A
F
F
Y
E
A
V
331
*
V
I
Q
T
V
E
L
P
E
I
G
L
V
315
K
T
F
W
S
F
G
L
I
L
*
E L
362
S
I
L
S
E
W
L
V
L
L
L
T
V
F
T
F
V
D V
S
L
L
E
N
T
I
V
L
L
F
M
S
A
S
183
187
L
V
S
D
V
H
K
K
S
T
T
V
R
C
T
S
V
A
V
V
V
A
F
L
L
M
S
H
F
L
A
V
L Y H L
G
G
G
V
S
F
Y
A
A
V
A
M
L
T
Y
M
V
L
I F I F
T
L
Y
L
P
V F F L
L Q S D
*
*
129
*
F
P
G
I
L
G
I
V
W
F
Y
V
G
V
V
S
Y
V
I
I
G
L
G
S I
T
F
G
N
L
Q
L
A
I
L
I
A
T
A
G
V
C
V
L
L
R
F
D
P
F
L
V
L
F
G
R
P
L
V
V
I
E
L
G
G
K
S
I
L
G
A
S
I
L
A
G
Y L L D
H
I
A
T A I
344
I S
349
E
F
F G S I
D N L L
I
F L
L
V
297
L
415
F E
L
L M
L
398
480
F
*
*
F
G
470
E
K
*
147
278
D
208
Y
T
G
F
G
V
L
226
K
C
A
W
A
S
V
157
L
Extra-cellular
H
F
P
L
M
V
N
Y
E H V G I V D
N
F
P
G
E T P
F
T
G
C
V
S H H W
I
I
A
G
L
N
V
G
N
Q I
G E
(b)
FIGURE 9.17 The evolutionary conservation profiles of EcNhaA, NHA2 and NHE1 (a) The membrane topology of NHE1 (residues
126 e 505). The residues are coloured according to their conservation grades. (b) The evolutionary conservation profiles of NHA2, NhaA, and
NHE1 mapped on the crystal structure of NhaA.
(Adapted from Landau et al., 2007 (a), and (b) from Schushan et al., 2010 . Reproduced with
permission from Elsevier.)
N
H
N
H
N
N
N
H
N
H
N
N
N
O
H
H
N
O
M +
O
N
H
H
N
N
N
O
N
H
H
N
N
N
H
N
H
N
FIGURE 9.18
The structure of a G-quartet.
(From Wozki & Schmidt, 2002. )
 
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