Chemistry Reference
In-Depth Information
FIGURE 8.20
Regulation of cellular copper transport.
(From van den Berghe & Klomp, 2010. Reproduced with permission from Springer
Verlag.)
while in zinc-replete medium, they are largely present in intracellular organelles. In addition, zinc homeostasis is
controlled at the transcriptional level by the zinc-responsive transcription factor MTF1, which protects cells
against zinc toxicity by increasing the expression of zinc-binding metallothionein genes and also acting on
a number of other zinc transporters. MTF1 can also be induced by copper, but this requires the presence of zinc-
saturated metallothionein.
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