Chemistry Reference
In-Depth Information
(a)
(b)
FIGURE 7.11
Structure of Cu-methanobactin from M. trichosporium. (a) Schematic diagram. (b) Ball-and-stick representation of crystal
structure. The copper ion is shown as a brown sphere.
(From
Balasubramanian & Rosenzweig, 2008
. Copyright 2008, American Chemical
Society.)
explained
short generation time and ease of production of large amounts of biomass relatively inexpensively on
defined media, not to mention the fact that it was the first complete eukaryote genome to be sequenced. Its genome
is small (6,043 genes), and unlike mammals, and it is comparatively easy to inactivate specific yeast genes. And
finally, it turns out that not only do many of the mechanisms involved in iron uptake and metabolism in higher
eukaryotes have homologous systems in yeast, but that many of the genes involved in iron acquisition in yeast have
homologous genes in higher eukaryotes which are frequently able to rescue yeast mutants defective in iron
acquisition and metabolism.
e
