Chemistry Reference
In-Depth Information
FIGURE 5.12
The reactions of the tricarboxylic acid cycle.
conversion of ADP to ATP). The central single bond between the methylene carbons of succinate is then oxidised
to a trans double bond (6) in a reaction catalysed by the FAD-dependent enzyme, succinate dehydrogenase.
Addition of water to fumarate catalysed by fumarase generates malate (7), which, in a final NAD
รพ
-dependent
oxidation, is converted to oxaloacetate (8), thus completing the cycle. The sequence of reactions (6
e
8) is also used
in the
b
-oxidation of fatty acids.
