Chemistry Reference
In-Depth Information
a central carrier protein onto which the precursors are loaded, which undergo a series of elongation steps on a mul-
timodular protein assembly line. The enterobactin synthetase consists of four proteins (EntBDEF) and is synthesised
from 2,3-dihydroxybenzoic acid (DHB). DHB is activated by EntE and transferred to the carrier protein domain of
EntB. The four-domain EntF protein together with EntE and EntB then carry out the stages of chain initiation,
elongation, and termination, which, after the hydrolysis of three molecules of DHB-serine, leads to release of the final
cyclized product by the thioesterase domain of EntF.
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