Chemistry Reference
In-Depth Information
Learning Objectives
1.
Know the meaning of: primary, secondary, and tertiary amine, amino group, aniline,
amine salt, quaternary ammonium salt.
2.
Know the meaning of: nitrous acid, diazonium ion, diazotization, azo coupling.
3.
Given the structure of an amine, identify it as primary, secondary, or tertiary.
4.
Given the structure of an amine, name it. Also, given the name of an amine, write its
structural formula.
5.
Explain the effect of hydrogen bonding on the boiling points of amines and their
solubility in water.
6.
Write an equation for the reaction between ammonia or an amine of any class and
an alkyl halide.
7.
Write an equation for the preparation of a given aromatic amine from the
corresponding nitro compound.
8.
Write an equation for the preparation of a given amine of the type RCH
2
NH
2
or
ArCH
2
NH
2
by reduction of the appropriate nitrile.
9.
Write an equation for the preparation of a secondary amine from a ketone, primary
amine, and sodium cyanoborohydride.
10.
Write an equation for the dissociation of an amine in water.
11.
Write an expression for
K
a
of any amine salt.
12.
Draw the important contributors to the resonance hybrid for an aromatic amine.
13.
Given the structures of several amines, rank them in order of relative basicity.
14.
Account for the difference in basicity between an aliphatic and an aromatic amine.
15.
Write an equation for the reaction of a given amine of any class with a strong acid.
Also, write an equation for the reaction of an amine salt with a strong base.
16.
Account for the basicity and acidity difference between amines and amides.
17.
Explain, with the aid of equations, how you can separate an amine from a mixture
containing neutral and/or acidic compounds.
18.
Explain how chiral amines can be used to resolve a mixture of enantiomeric acids.
19.
Write an equation for the reaction of a given primary or secondary amine with an
acid anhydride or acyl halide.
20.
Write the steps in the mechanism for acylation of a primary or secondary amine.
21.
Write an equation for the diazotization of a given primary aromatic amine.
22.
Write the equations for the reaction of an aromatic diazonium salt with: aqueous
base; HX + Cu
2
X
2
(X = Cl, Br); KCN + Cu
2
(CN)
2
; HBF
4
; and H
3
PO
2
.
23.
Write an equation for the coupling of an aromatic diazonium salt with a phenol or
aromatic amine.
