Biomedical Engineering Reference
In-Depth Information
Chapter 12
N
EW
P
ROBIOTIC
P
RODUCT FOR
P
REVENTION AND
T
REATMENT OF
E
NTERITIS AND
R
ESPIRATORY
D
ISEASES OF
F
ARM
S
TOCK
N. V. Sverchkova,
1,
*
M. S. Kolosovskaya,
1
T. V. Romanovskaya,
1
G. V. Zhuk,
1
E. I. Kolomiets,
1
P. A. Krasochko
2
and Y. V. Lomako
2
1
Institute of Microbiology, Belarus National Academy of Science, Minsk, Belarus
2
Institute of Experimental Veterinary Science, Minsk, Belarus
A
BSTRACT
Application prospects of sporulating bacterial strain
Bacillus
subtilis for elaboration
of new probiotic used in prevention and treatment of respiratory diseases in farm stock
were demonstrated. Pilot-plant technology of Bacinil manufacturing and application was
developed. Prophylactic and therapeutic efficiency of Bacinil in cases of enteritis and
respiratory diseases of farm animals was established. Bacinil was registered by
Vetbiopharm Council and entered into the list of veterinary drugs authorized for use in
Belarus.
Keywords:
Sporulating bacteria, Bacillus subtilis, fermentation, biological control, animal
pathogens, biotechnology, probiotic
One of the problems of modern dairy and meat stock breeding is increased incidence of
infectious diseases caused by facultatively pathogenic bacteria showing a broad spectrum of
virulence (enterotoxigenecity, adhesive capacity, haemolytic activity, drug resistance). Latest
reports indicate general epizootic significance of gastrointestinal pathologies in young
animals manifested as diarrhea syndrome [1, 2]. The reasons inducing gastroenteritis cases in
animals may be defects in rearing conditions, malnutrition, disbalance in gut microbiota,
immune deficiency, often accompanied by activation of facultatively pathogenic microbial
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