Biomedical Engineering Reference
In-Depth Information
3
Gold Nanoparticle-Based Electrochemical
Biosensors for Medical Applications
Ülkü Anik
Muğla Sıtkı Koçman University, Faculty of Science, Chemistry Department,
Muğla, Turkey
Abstract
Recent developments about the attractive properties of nanoparticles increase
interest about their applicability in biosensing areas resulting in great progress in
the development of nanomaterial-based biosensors. h e usage of metal nanopar-
ticle superstructures for the organization of electrochemical sensing devices is
an extremely promising prospect. Gold nanoparticle (AuNP) is a kind of metal
nanoparticle which can help proteins retain their biological activity upon adsorp-
tion. Because of its large surface area and good electronic properties, AuNP has
been extensively used in the construction of electrochemical sensors and biosen-
sors. h e aim of this chapter is to give detailed information about AuNP-based
electrochemical biosensors and their usage in medical application. For this pur-
pose, i rst of all the preparation of AuNP was given. h en AuNP modii ed elec-
trodes were examined and usage of these electrodes as biosensor transducers for
medical applications were discussed.
Keywords:
Gold nanoparticles, electrochemical biosensors, medical applications
3.1 Introduction
It is very important to monitor health status, disease onset and progres-
sion, and the treatment outcome in health care research. On the other
hand, early disease diagnosis is crucial for patient survival and sensitive
and specii c methods are required for that. In recent years, the demand has
