Biomedical Engineering Reference
In-Depth Information
monomer via metal coordination-chelation interactions and dipicolinic
acid (DPA), which is a main participant of
Bacillus
spores and has been
used as a template. Nanoshell sensors with templates give a cavity that is
selective for DPA. h e DPA can simultaneously chelate to Cr(III) metal
ion and i t into the shape-selective cavity. h us, the interaction between
Cr(III) ion and free coordination spheres has an ef ect on the binding abil-
ity of the gold-silver nanoclusters nanosensor. h e binding ai nity of the
DPA imprinted nanoclusters has been investigated by using the Langmuir
and Scatchard methods, and determined ai nity constants were found as
18×10
6
mol L
−1
and 9
×
10
6
mol L
−1
, respectively. 4-Nonylphenol (4-NP)
was reported to af ect the health of wildlife and humans through altering
endocrine function. Huang
et al.
developed a novel electrochemical sen-
sor for sensitive and fast determination of 4-NP [70]. h e TiO
2
-NPs and
AuNPs were introduced for the enhancement of electron conduction and
sensitivity. h e 4-NP-imprinted functionalized AuNPs composites with
specii c binding sites for 4-NP were modii ed on electrode (Figure 12.31).
Rebinding experiments were carried out to determine the specii c bind-
ing capacity and selective recognition. h e linear range was over the range
from 4.80×10
−4
to 9.50×10
−7
mol L
−1
, with the detection limit of 3.20×10
−7
mol L
−1
(S/N=3). h e sensor was successfully employed to detect 4-NP in
real samples.
In another work, the preparation of CNTs functionalized with MIPs for
advanced removal of estrone has been reported by Gao
et al.
[71]. h e
CNTs@Est-MIPs nanocomposites with a well-dei ned core-shell structure
AuNPs
Cysteamine
Gold
electrode
MIP with
template
After remove
template
TiO
2
-NH
2
Figure 12.31
Simplii ed sketch of the fabrication process of the electrode [70].
