Biomedical Engineering Reference
In-Depth Information
Physisorption
MWCNTs
DMAc/LiCl
Imprinted cavities
Chitin
Cholesteroyl
chloroformate
Removal of
template
TDI
Chitin-Chol
MIP shell
MWCNT@MIP
Graphite powder
Figure 12.25
Schematic of the synthesis of MWCNT@MIP and preparation of ceramic
carbon materials by doping MWCNT@MIP (Reproduced with permission from [58]).
when integrated onto sensing transducer. We have reported on the prepa-
ration of such material by grat -polymerizing MIP on the surface of car-
bon nanotube (CNT) using MIP as a probe material for chemical sensor
fabrication. h e MIP is characterized by Fourier transform infrared analy-
sis and UV-Vis analysis. Batch binding analysis is carried out to analyze
selective recognition of MIP towards serine (amino acid). h e SEM images
showed the structure of MIP on CNT surface. h e serine-imprinted poly-
mer grat ed on CNT possessed higher binding capacity for serine than
nonimprinted polymer (NIP) grat ed on CNT.
An insulin-imprinted polymer synthesized over the surface of vinyl
group-functionalized multiwalled carbon nanotubes using phosphotidyl-
choline-containing functional monomer and crosslinker was also devel-
oped by Prasad
et al.
[60]. Phosphotidylcholine is a major component of all
biological membrane; its incorporation in polymer backbone assures water
compatibility, biocompatibility and specii city to molecularly imprinted
nanomaterials, without any cross-reactivity or interferences from biologi-
cal sample matrices. An electrochemical sensor fabricated by modifying
multiwalled carbon nanotubes-molecularly imprinted polymer onto the
pencil graphite electrode,was used for trace level detection of insulin in
