Biomedical Engineering Reference
In-Depth Information
Table 2.1
Selected studies of germ cell-derived pluripotent stem cells
Kanatsu-
Shinohara
et al. (
2004
)
Guan et al.
(
2006
)
Seandel et al.
(
2007
)
Izadyar et al.
(
2008
)
Ko et al.
(
2009
)
Conrad et al.
(
2008
)
Kossack
et al. (2009)
Parameter
Age/species of donor
Neonatal/
mouse
Adult/
mouse
Adult/
mouse
Neonatal-adult/
mouse
Adult/
mouse
Adult/human
Adult/
human
Designation for pluripotent cell lines
mGS
maGSC
MASC
mGC
gPS
haGSC
hMGSC
Precursor population kept in long-term
culture
Ye s
No
Ye s
No
Ye s
No
No
Precursor population restores
spermatogenesis
a
Ye s
Ye s
Ye s
No (c-kit+)
Ye s
N/A
N/A
Precursor population forms teratoma
No
N/A
No
N/A
No
N/A
N/A
Pluripotent stem cells differentiate
in vitro
Ye s
Ye s
Ye s
Ye s
Ye s
Ye s
Ye s
Pluripotent stem cells form teratoma
Ye s
Ye s
Ye s
No
Ye s
Ye s
No
c
Precursor population forms chimeric
blastocysts
No
Ye s
No
b
N/A
N/A
N/A
N/A
Pluripotent stem cells form chimeric
blastocysts
Ye s
N/A
Ye s
Ye s
Ye s
N/A
N/A
a
In spermatogonial stem cell-type transplantation assay
b
Seandel et al. unpublished data
c
Additionally, studies by Golestaneh et al. (
2009
) and Mizrak et al. (2010) did not yield large, complex teratomas from the ES-like cells.
N/A
not
applicable
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