Biomedical Engineering Reference
In-Depth Information
Table 9.2
Comparison of effects of comparable doses of radiation on
the spermatogenic cells of mouse, rat, monkey, and human
Stem spermatogonia
Differentiating spermatogonia
Later germ cell stages
Development
during
recovery
Development
during
recovery
Cell stage: species
(strain)
Recovery
of numbers
Survival
Immediate effects
Immediate effects
Mouse
Some survive
doses up to
16 Gy, Killed
by some
alkylating
agents,
Adriamycin,
and radiation
Progressive
recovery
(immediate
or after
8 weeks)
Very sensitive
to direct
killing by
radiation and
chemotherapy
Develop
normally
from
surviving
stem
cells
Spermatocytes
moderately
resistant
and
spermatids
highly
resistant to
radiation
Develop normally
although
efficiency may
be reduced
Rat (several inbred
strains)
Some survive doses
up to 10 Gy
(No data on
recovery of stem
cell numbers)
Very sensitive to
direct killing by
radiation
Sensitive to
chemotherapy too
Strong block
of
differentiation
after radiation
and some
chemothera-
peutic
drugs
Relatively
resistant
to irradiation
Failure of cells to
progress through
differentiation
Rat (Sprague-Dawley) Some survive doses
up to 10 Gy
Progressive recovery
(may be delayed
until 8 weeks)
Very sensitive to direct
killing by radiation
Sensitive to
chemotherapy too
Variable,
intermediate
between mice
and inbred
rats
Resistant (no
cytotoxic
effects of
3 Gy)
Develop normally
after 3 Gy
Monkey (macaque)
Most killed by doses
of 1-4 Gy.
Killing of A
dark
is
delayed
Recovery begins
about 6 weeks
after 0.5-2 Gy
Very sensitive to direct
killing by radiation
Develop from
surviving
stem cells
after transient
block
(~3 months)
Resistant
(negligible
cytotoxic effects
of 4 Gy)
Develop normally
after 4 Gy
Search WWH ::
Custom Search