Biomedical Engineering Reference
In-Depth Information
Table 9.1
Effectiveness of anticancer gonadotoxic agents in different species at killing stem spermatogonia
Agent
Mouse
Rat
Macaque
Human
Radiation
++ (Withers et al.
1974
)
++ (Delic et al.
1987
)
+++ (van Alphen et al.
1988a
)
+++ (Rowley et al.
1969
)
Busulfan
++ (Bucci and Meistrich
1987
)
+ (Ogawa et al.
1999
)
+ (Hermann et al.
2007
)
++ (Sanders
2004
)
Cyclophosphamide
− (Lu and Meistrich
1979
)
± (Meistrich et al.
1995
)
n.d.
++ (Meistrich et al.
1992
)
Chlorambucil
+ (Meistrich et al.
1982
)
+ (Delic et al.
1986b
)
n.d.
++ (Clark et al.
1995
)
Cisplatin
− (Meistrich et al.
1982
)
− (Huang et al.
1990
)
n.d.
++ (Hansen et al.
1989
; Meistrich
et al.
1989
)
Melphalan
n.d.
n.d.
n.d.
+ (Jacob et al.
1998
)
Procarbazine
+ (Meistrich et al.
1982
)
+ (Delic et al.
1986a
;
Parchuri et al.
1993
)
(+) (
a
Sieber et al.
1978
)
+ (Da Cunha et al.
1984
; Sherins
and DeVita
1973
)
Thio-TEPA
++ (Meistrich et al.
1982
)
n.d.
n.d.
+ (Anserini et al.
2002
)
Doxorubicin
++ (Lu and Meistrich
1979
)
++ (Lui et al.
1986
)
n.d.
± (Da Cunha et al.
1983
)
Amsacrine
− (Da Cunha et al.
1985
)
−
b
n.d.
− (Da Cunha et al.
1982
)
+, ++, +++: Relative effectiveness at stem cell killing
±: Stem cell killing cannot be demonstrated with the agent given alone but has additive effect on stem cell killing with other agents,
−: No stem cell killing
n.d: Testing of that agent was not done in that species
a
Germinal aplasia observed while receiving drug treatment but no analysis was performed after cessation of drug administration
b
M.F. da Cunha and M.L. Meistrich, unpublished results
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