Biomedical Engineering Reference
In-Depth Information
TABLE 18.1
Conditions of Fabrication of a Series of Model Nanoparticles Coated with Dextran
as Polysaccharides and Corresponding Models Deduced from the Characteristics
of the Copolymers That Composed Them
Method of
Polymerization
Conditions of
Polymerization
Structure of the Copolymer
PIBCA
*
/Dextran
Model Proposed for
the Nanoparticles
Name
A1
Anionic
polymerization
pH 1
Dextran 70 kDa 1.3%
2
1
D
H
: 86 nm
ζ = −8.7 mV
A2
Anionic
polymerization
pH 2.5
Dextran 70 kDa 1.3%
4
1
D
H
: 181 nm
ζ = −1.1 mV
R1
Radical
polymerization
pH 1
Dextran 70 kDa 1.3%
1
1
D
H
: 224 nm
ζ = −11.6 mV
R2
Radical
polymerization
pH 1
Dextran 70 kDa 0.5%
D
H
: 180 nm
R3
Radical
polymerization
pH 1
Dextran 15 kDa 1.3%
D
H
: 200 nm
ζ = −19 mV
*PIBCA: poly(isobutylcyanoacrylate).
larger objects that could correspond to micelles (Bertholon et al., 2006b). True solutions of copo-
lymers occurred at lower concentrations than that required to perform analyses with the usual
methods applied to characterize polymers from solutions. To turn around this analytical prob-
lem, methods of the selective degradation of two types of polymers included in the copolymer
were set up (Figure 18.3
)
.
