Biomedical Engineering Reference
In-Depth Information
TABLE 10.3
Physical Features of TiO 2 Nanoparticles and Membrane State Values after TiO 2 Cellular
Exposures Used in the Multivariate Linear Regression Analyses and LDA Classification
x 0 Eng. Size
(nm)
x 1 Size in Water
(nm)
x 2 Size in PBS
(nm)
x 5 Zeta Potential
(mV)
y Membrane
Damage (units/L)
x 4 Conc. (mg/L)
30
125
1250
25
−10
0.90
30
102
987
25
1.00
−12
30
281
1543
50
−15
0.75
30
101
1045
50
−9
0.70
30
299
1754
100
1.04
−11
30
134
961
100
−11
1.09
30
600
1876
200
−12
1.15
30
298
1165
200
1.20
−12
45
129
2567
25
−9
0.90
45
129
2309
25
0.85
−10
45
201
2431
50
0.75
−9
45
201
2987
50
−11
0.78
45
451
2941
100
1.40
−11
45
451
1934
100
−9
1.50
45
876
1965
200
−11
1.35
45
876
2109
200
1.40
−10
125
136
3215
25
−11
1.25
125
136
2667
25
1.17
−10
125
149
3782
50
1.00
−10
125
149
2144
50
−15
1.10
125
343
3871
100
1.50
−12
125
343
2890
100
−9
1.42
125
967
3813
200
−9
1.60
125
967
2671
200
1.65
−8
Source: Reprinted with permission from Sayes, C. and Ivanov, I. 2010. Risk. Anal . 30, 1723-1734. With permission.
600
400
200
0
-200
1000
-400
800
600
-600 0
400
50
X 1
100
200
150
200
X 4
0
250
FIGURE 10.6 Classification of dense cell membrane samples versus disrupted cell membrane samples after
exposure to TiO 2 using the combination of three features: X 1 = size in water, X 4 = concentration, and X 5 = zeta
potential. Circles represent no membrane damage and triangles represent damaged membrane. (Reprinted
with permission from Sayes, C. and Ivanov, I. 2010. Risk. Anal . 30, 1723 -1734.)
 
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