Biomedical Engineering Reference
In-Depth Information
TABLE 7.1
Preparation Techniques of PNs with Examples
Method
Drug
Use
Polymer
Nanoprecipitation [9-12]
Paclitaxel
Loperamide
Anticancer
Opioid agonist
TPGS-functionalized PLGA
PLGA-PEG-PLGA triblock
copolymer
Dextran, PLA, and DPPE
Eudragit S100
Mitoxantrone
Prednisolone
Anticancer
Glucocorticoid
Emulsification-solvent
evaporation [13-16]
Latanoprost acid
Amylin
Ketoprofen
Antihypertensive
Pancreatic hormone
NSAID
PLA-PEG
Poly-caprolactone
Eudragit E100 and
Eudragit RS
PCL and PLGA
Levofloxacin
Quinolone antibiotic
Emulsification-solvent
diffusion [17-19]
Triamcinolone acetonide
Daunorubicin
5-Fluorouracil
α-Tocopherol acetate
Endotoxin-induced uveitis
Anticancer
Anticancer
Antioxidant
PLGA
PLGA and PDLLA
N
-succinyl-chitosan
Poly-(lactide)
Emulsification-salting out
[20-22]
Ibuprofen
Celecoxib
Savoxepine
NSAID
NSAID
Atypical neuroleptic
Eudragit L100-55 and PVAL
PLGA
PLA
Using supercritical fluids
[23-25]
Dexamethasone
Glucocorticoid
PCL with mesoporous
MCM-41 silica
PLGA
PLLA
Plasmid DNA
Retinyl palmitate
Antioxidant
Layer-by-layer synthesis or
polymerization [26,27]
Steroidal aromatase inhibitor, exemestane in cPCL synthesized by ring opening
polymerization of caprolactone
Tryptophan hydroxylase-2 gene in magnetic PMMA/PEI shell
TABLE 7.2
Preparation Techniques of SLN with Examples
Preparation Techniques
Drug
Use
Lipids
High-pressure homogenization
[28-30]
A. Hot homogenization method
Triamcinolone
Acetonide acetate
Nitredipine
Lutein
Cyclosporin-A
Corticosteroid
Ca channel blocker
Antioxidant
Immunosuppressant
Antitumor
Glyceryl palmitostearate
Glyceryl tripalmitate
Cetyl palmitate
Glyceryl monostearate
Cetyl palmitate
B. Cold homogenization method
Vitamin E
Vinorelbin-bitartrate
Sunscreen
Antitumor
Acetyl palmitate
Glyceryl monostearate
Microemulsion technique [31-33]
Curcuminoides
Ketoprofen
Quercetin
Topotecan
Tetrandine
Curcumin
NSAID
Alzheimer's
Cytotoxic
Antitumor
Stearic acid
Glyceryl monostearate
Bees wax
Carnauba wax
Compitrol 888 ATO
Double emulsion technique
[34-36]
Ceramide
Insulin
5-Flurouracil
Topical
Diabetes
Chemotherapy
Tripalmitin
Stearic acid
Palmitic acid
Glyceryl monostearate
Ultrasonication technique
Indomethacin
Analgesic
Glyceryl behenate
Tribehenate
